Factor label method chemistry

If I removed a transcription factor from a a mushroom. How would I check which genes were affected by this removal?

2023.06.04 20:24 eldobhatofiok If I removed a transcription factor from a a mushroom. How would I check which genes were affected by this removal?

What transformation method would you use to remove the transcription factor and why the given method is beneficial? I'm trying to construct an experiment with an Aspergillus sp. And I'd like my experiment to cost as less as possible
submitted by eldobhatofiok to labrats [link] [comments]

2023.06.04 20:24 eldobhatofiok If I removed a transcription factor from a a mushroom. How would I check which genes were affected by this removal?

What transformation method would you use to remove the transcription factor and why the given method is beneficial? I'm trying to construct an experiment with an Aspergillus sp. And I'd like my experiment to cost as less as possible
submitted by eldobhatofiok to biology [link] [comments]

2023.06.04 19:56 Larsonkaser21 Dishwasher vs. Hand Washing

Hey all—new to the thread. Wanted to open up a discussion as I’ve been pondering getting a Bosch dishwasher with the assumption it would like last 10+ years.
We are first time homeowners currently hand-washing. Can anyone with the experience in transitioning from one to the other speak to the efficiency, tradeoff, and ultimately any long-term savings generated by one method vs. the other? Let me know your thoughts…also factoring in the marginal time savings in having to hand-wash (sorry if this is more appropriate for another thread, but the ultimate impetus driving this decision is frugality).
Thanks! Looking forward to feedback.
submitted by Larsonkaser21 to Frugal [link] [comments]



create create very simple docker full os but it needs very complex steps

  1. install gnu linux for host os ex= debian stable
  2. install docker in host os sh sudo apt install docker* docker-compose*
  3. pull docker gnu linux os for docker linux os ex= kali linux rolling sh sudo docker pull kalilinux/kali-rolling
  4. make audio fix (pulse audio fix) before start the dcoker image
    • create file named pulseaudio.socket in /home/usepulse
    • in that file write this text and save
```text default-server = unix://home/usepulse/pulseaudio.socket

Prevent a server running in the container

autospawn = no daemon-binary = /bin/true

Prevent the use of shared memory

enable-shm = false Share socket and config file with docker and set environment variables PULSE_SERVER and PULSE_COOKIE. Container user must be same as on host: ```

for intel gpu

dpkg --add-architecture i386 && sudo apt update apt install libvulkan1 libvulkan1:i386 mesa-vulkan-drivers mesa-vulkan-drivers:i386 vulkan-tools* -y apt install wine64 lutris*

add root password


add user

adduser username usermod -aG sudo username 9. to save the container into image - open new terminal - check the container id sh sudo docker ps -a - save the container into docker image sh sudo docker container commit --pause=false id-container nama-image:label


sudo docker container commit --pause=false c092aa5afec0 kali-linux:kali-linux-docker-full-os ``` it is very complex steps and needs long time :), so please make official full os for us .thanks :)

simple use case for docker full os

docker full os can make better gaming expirence

because docker full os kali linux rolling (debian testing) have newer mesa driver than debian stable , so it make game in docker full os better. the step are : - run the ali-linux-docker-full-os sh sudo docker run -ti --device=/dev/dri:/dev/dri \ --privileged --cap-add=ALL --device /dev/snd \ --volume /dev:/dev -v /dev:/dev --group-add audio \ -v /varun/docker.sock:/host/varun/doc -v /:/media/prime \ --env PULSE_SERVER=unix:/home/usepulse/pulseaudio.socket \ --env PULSE_COOKIE=/home/usepulse/pulseaudio.cookie \ --volume /home/usepulse/pulseaudio.socket:/home/usepulse/pulseaudio.socket \ --volume /home/usepulse/pulseaudio.client.conf --publish= \ --publish= --group-add video --volume="/tmp/.X11-unix:/tmp/.X11-unix" \ --env="DISPLAY" -e XAUTHORITY=/root/.Xauthority \ --name dockerfullos-001 imageid tipe lutris - lutris will run in host os - setting the lutris and play the game :)

docker full os can sutitude the vm

because docker full os is a native os like chroot so it has a native performance like the host, how to do it ?, it very imple

method A, acces all docker full os apps from host


run the immage

sudo docker run -ti --device=/dev/dri:/dev/dri \ --privileged --cap-add=ALL --device /dev/snd \ --volume /dev:/dev -v /dev:/dev --group-add audio \ -v /varun/docker.sock:/host/varun/doc -v /:/media/prime \ --env PULSE_SERVER=unix:/home/usepulse/pulseaudio.socket \ --env PULSE_COOKIE=/home/usepulse/pulseaudio.cookie \ --volume /home/usepulse/pulseaudio.socket:/home/usepulse/pulseaudio.socket \ --volume /home/usepulse/pulseaudio.client.conf --publish= \ --publish= --group-add video --volume="/tmp/.X11-unix:/tmp/.X11-unix" \ --env="DISPLAY" -e XAUTHORITY=/root/.Xauthority \ --name dockerfullos-001 imageid ``` we can use rofi or cairo-dock to lunch the docker full os apps

method B, we can access full gui of docker full os via xrdp

how to do it 1. run the docker image sh sudo docker run -ti --device=/dev/dri:/dev/dri \ --privileged --cap-add=ALL --device /dev/snd \ --volume /dev:/dev -v /dev:/dev --group-add audio \ -v /varun/docker.sock:/host/varun/doc -v /:/media/prime \ --env PULSE_SERVER=unix:/home/usepulse/pulseaudio.socket \ --env PULSE_COOKIE=/home/usepulse/pulseaudio.cookie \ --volume /home/usepulse/pulseaudio.socket:/home/usepulse/pulseaudio.socket \ --volume /home/usepulse/pulseaudio.client.conf --publish= \ --publish= --group-add video --volume="/tmp/.X11-unix:/tmp/.X11-unix" \ --env="DISPLAY" -e XAUTHORITY=/root/.Xauthority \ --name dockerfullos-001 imageid
  1. edit the xrpd config in that docker full os sh nano /etc/xrdp/xrdp.ini # change to port to the open port 3351 # it will make the xrdp ip # restart xrdp server service xrdp restart # start pulse audio pulseaudo --start
  2. install kdrc (rdp client) in host os
  3. conect the xrdp using kdrc with the xrpd ip

kdc setting

screen setting = 1024x800 audio = in this computer --- pulse audio 32bit color :) ``` 5. enjoy :) we can use docker full os with full gui in krdc :)

docker full os can use for simple cloud computing / cloud gaming

how to do it ?, it very easy 1. run the docker image, we can run multiple docker full image in single server - terminal 1 ```sh sudo docker run -ti --device=/dev/dri:/dev/dri \ --privileged --cap-add=ALL --device /dev/snd \ --volume /dev:/dev -v /dev:/dev --group-add audio \ -v /varun/docker.sock:/host/varun/doc -v /:/media/prime \ --env PULSE_SERVER=unix:/home/usepulse/pulseaudio.socket \ --env PULSE_COOKIE=/home/usepulse/pulseaudio.cookie \ --volume /home/usepulse/pulseaudio.socket:/home/usepulse/pulseaudio.socket \ --volume /home/usepulse/pulseaudio.client.conf --publish= \ --publish= --group-add video --volume="/tmp/.X11-unix:/tmp/.X11-unix" \ --env="DISPLAY" -e XAUTHORITY=/root/.Xauthority \ --name dockerfullos-001 imageid

change xrdp and ssh port accordingly :)

how to change ssh port

nano /etc/ssh/sshd_config

change the port to 51

- terminal 2 sh sudo docker run -ti --device=/dev/dri:/dev/dri \ --privileged --cap-add=ALL --device /dev/snd \ --volume /dev:/dev -v /dev:/dev --group-add audio \ -v /varun/docker.sock:/host/varun/doc -v /:/media/prime \ --env PULSE_SERVER=unix:/home/usepulse/pulseaudio.socket \ --env PULSE_COOKIE=/home/usepulse/pulseaudio.cookie \ --volume /home/usepulse/pulseaudio.socket:/home/usepulse/pulseaudio.socket \ --volume /home/usepulse/pulseaudio.client.conf --publish= \ --publish= --group-add video --volume="/tmp/.X11-unix:/tmp/.X11-unix" \ --env="DISPLAY" -e XAUTHORITY=/root/.Xauthority \ --name dockerfullos-002 imageid

change xrdp and ssh port accordingly :)

- terminal 3 sh sudo docker run -ti --device=/dev/dri:/dev/dri \ --privileged --cap-add=ALL --device /dev/snd \ --volume /dev:/dev -v /dev:/dev --group-add audio \ -v /varun/docker.sock:/host/varun/doc -v /:/media/prime \ --env PULSE_SERVER=unix:/home/usepulse/pulseaudio.socket \ --env PULSE_COOKIE=/home/usepulse/pulseaudio.cookie \ --volume /home/usepulse/pulseaudio.socket:/home/usepulse/pulseaudio.socket \ --volume /home/usepulse/pulseaudio.client.conf --publish= \ --publish= --group-add video --volume="/tmp/.X11-unix:/tmp/.X11-unix" \ --env="DISPLAY" -e XAUTHORITY=/root/.Xauthority \ --name dockerfullos-002 imageid

change xrdp and ssh port accordingly :)


each docker full os will run natively and independenly

we can acces it from the ost os with ip localhost:xrdp post ( with kdrc client :), we can also accest in from diffierent gnu linux computer in the same lan / wifi local network with the ip from host os that give by the router explampe etc and xrdp port :) with kdrc

exaample xrdp

dockerfullos-001 = dockerfullos-002 = dockerfullos-003 =

example of ssh

dockerfullos-001 = dockerfullos-002 = dockerfullos-003 = enjoy the docker full os for cloud computing :), all the apps fro docker full os will run natively in kdrc in the client compuputer :), for gaming we can use emulator (ps1, ps2, psp, mame etc) , steam , lutris, wine etc :)

wine / lutris fix

wine / lutris sometime will error in docker full os, how to fix it 1. open lutris 2. setting the game with lutris 3. in the game menu , select wine regristry 4. edit the hcu ----- wine 5. add key X11 DRIVER 6. add string "UseXVidMode"="N" 7. add string UseXVidMode ----- edit the VALUE to N 8. add string "UseXRandR"="N" 9. add string UseXRandR ----- edit the VALUE to N 10. close wine
thanks :)


This text use creative common license
submitted by Antique_Annual_8158 to selfhosted [link] [comments]

2023.06.04 19:44 Terrabites Prevent Network Manager delay after sleep

Ubuntu 20.04.1 Kernel 5.15.0-71
After coming back from a sleep state my network manager takes a few seconds to reconnect. Would like to know if I can prevent this from happening by possibly enabling NIC from going into a low power state or some other method. I have provided the output from system logs after coming out of sleep state. Please advise if there are any further details needed.
I am looking for any ideas or suggestions on overcome this issue. systemd[1]: NetworkManager-dispatcher.service: Deactivated successfully. NetworkManager[792]: [1685811431.1067] manager: sleep: wake requested (sleeping:yes enabled: yes) NetworkManager[792]: [1685811431.1068] device (enp5s0): state change: unmanaged -> unavailable (reason 'managed', sys-iface-state: 'external') NetworkManager[792]: [1685811431.2621] manager: NetworkManager state is now DISCONNECTED NetworkManager[792]: [1685811434.7142] device (enp5s0): carrier: link connected NetworkManager[792]: [1685811434.7144] device (enp5s0): state change: unavailable -> disconnected (reason 'carrier-changed', sys-iface-state: 'managed') NetworkManager[792]: [1685811434.7151] policy: auto-activating connection 'Wiredconnection 1' (d2243b54-dd72-389f-bce6-3669116dacc8) NetworkManager[792]: [1685811434.7154] device (enp5s0): Activation: starting connection 'Wired connection 1' (d2243b54-dd72-389f-bce6-3669116dacc8) NetworkManager[792]: [1685811434.7155] device (enp5s0): state change: disconnected -> prepare (reason 'none', sys-iface-state: 'managed') NetworkManager[792]: [1685811434.7156] manager: NetworkManager state is now CONNECTING NetworkManager[792]: [1685811434.7157] device (enp5s0): state change: prepare ->config (reason 'none', sys-iface-state: 'managed') NetworkManager[792]: [1685811434.7160] device (enp5s0): state change: config -> ip-config (reason 'none', sys-iface-state: 'managed') NetworkManager[792]: [1685811434.7161] dhcp4 (enp5s0): activation: beginning transaction (timeout in 45 seconds) NetworkManager[792]: [1685811442.7904] dhcp4 (enp5s0): state changed new lease, address=192.168.xx.xx dbus-daemon[790]: [system] Activating via systemd: service name='org.freedesktop.nm_dispatcher' unit='dbus-org.freedesktop.nm-dispatcher.service' requested by ':1.5' (uid=0 pid=792 comm="/ussbin/NetworkManager --no-daemon " label="unconfined") NetworkManager[792]: [1685811442.7918] device (enp5s0): state change: ip-config -> ip-check (reason 'none', sys-iface-state: 'managed') NetworkManager[792]: [1685811442.8023] device (enp5s0): state change: ip-check -> secondaries (reason 'none', sys-iface-state: 'managed') NetworkManager[792]: [1685811442.8025] device (enp5s0): state change: secondaries -> activated (reason 'none', sys-iface-state: 'managed') NetworkManager[792]: [1685811442.8028] manager: NetworkManager state is now CONNECTED_LOCAL NetworkManager[792]: [1685811442.8030] manager: NetworkManager state is now CONNECTED_SITE NetworkManager[792]: [1685811442.8031] policy: set 'Wired connection 1' (enp5s0)as default for IPv4 routing and DNS NetworkManager[792]: [1685811442.8036] device (enp5s0): Activation: successful, device activated. NetworkManager[792]: [1685811442.8039] manager: NetworkManager state is now CONNECTED_GLOBAL systemd[1]: NetworkManager-dispatcher.service: Deactivated successfully.
submitted by Terrabites to linuxquestions [link] [comments]

2023.06.04 19:26 Asleepfarm420 Resources for Relationship Abuse and Intimate Partner Violence

What is relationship abuse?
Relationship abuse is a pattern of abusive and coercive behaviors used to maintain power and control over a former or current intimate partner. Abuse can be emotional, financial, sexual or physical and can include threats, isolation, and intimidation. Abuse tends to escalate over time. When someone uses abuse and violence against a partner, it is always part of a larger pattern of control.
Warning signs of abuse:

Types of abuse:
Physical abuse is any intentional, unwanted contact with you or something close to your body, or any behavior that causes or has the intention of causing you injury, disability, or death.
Emotional abuse & verbal abuse includes non-physical behaviors such as threats, insults, constant monitoring or “checking in,” excessive texting, humiliation, intimidation, isolation, or stalking.
Sexual abuse refers to any behavior that pressures or coerces someone to do something sexually that they don’t want to do. It can also refer to behavior that impacts a person’s ability to control their sexual activity or the circumstances in which sexual activity takes place, including oral sex, rape, or controlling reproductive methods and choices.
Financial abuse often operates in more subtle ways than other forms of abuse, but it can be just as harmful to those who experience it.
Modern conditions of stark economic inequality mean that financial security is directly tied to our health and wellbeing. No one has the right to use money or how you choose to spend it to control your actions or decisions, and no one should control your ability to work.
Digital dating abuse is the use of technologies like texting and social media to bully, harass, stalk, or intimidate a partner. This behavior is often a form of verbal or emotional abuse, conducted online.
Stalking occurs when someone watches, follows, or harasses you repeatedly, making you feel afraid or unsafe.
Avoid victim blaming
Why is it dangerous?
Victim-blaming attitudes marginalize the victim/survivor and make it harder to come forward and report the abuse. If the victim/survivor knows that you or society blames survivors for abuse, they will not feel safe or comfortable coming forward and talking to you.
Victim-blaming attitudes also reinforce the manipulative tactics that abusers use to control their partner; abusers tell survivors that it is their fault this is happening. Committing violence is always the choice of the person who is abusing. It is NOT the victim/survivor’s fault or responsibility to fix the violence that an abuser is committing against them. By engaging in victim-blaming attitudes, society allows abusive people to perpetrate relationship abuse or sexual assault while avoiding accountability for those actions.
Victim-blaming attitudes prevent society from acknowledging and changing toxic masculinity and rape culture.
Where does it come from?
In order to stop victim-blaming, it is helpful to understand why it occurs in the first place. One reason that people blame a victim/survivor is to distance themselves from an unpleasant occurrence. This gives a false sense that this could not happen to them. By labeling or accusing the victim/survivor, others can see the victim/survivor as different from themselves. People use the Just World theory, Invulnerability theory, and Assumptive World theory in an attempt to feel like they have control over situations where they do not have control. People reassure themselves by thinking, “Because I am not like the victim/survivor, because I do not do XYZ, this would never happen to me.” We need to help people understand that a survivor’s actions do not contribute to a perpetrator’s (those that choose to harm decision to commit relationship abuse and sexual violence. It is our responsibility as members of society to support survivors and hold abusers accountable.)
What does victim blaming look like?
Common Victim Blaming Statements:
Example of Victim-Blaming Attitude:
Reality: This statement assumes that the victim is equally to blame for the abuse, when in reality, abuse is a conscious choice made by the abuser. Abusers have a choice in how they react to their partner’s actions. Options besides abuse include: walking away, talking in the moment, respectfully explaining why an action is frustrating, breaking up, etc. Additionally, abuse is not about individual actions that incite the abuser to hurt the victim/survivor, but rather about the abuser’s feelings of entitlement to do whatever the abuser wants to their partner. When friends and family remain neutral about the abuse and say that both people need to change, they are taking away responsibility from the perpetrator (those that choose to harm, thereby colluding with/supporting the abusive partner and making it less likely that the survivor will seek support.)
Victim Blaming in Language:One of the biggest sources of victim blaming is the way we talk about it. Language surrounding abuse and sexual assault immediately puts our attention on the victim instead of the perpetrator. This is a demonstration developed by Julia Penelope and frequently used by Jackson Katz to show how language can be victim blaming:
As you can see, the focus has shifted entirely to Mary instead of John, encouraging the audience to focus on the survivor’s actions instead of the perpetrator’s actions. The solutions regarding prevention become focused on what Mary can do differently, not on what John can do differently, and not on how society creates a culture that supports John’s behavior.
What can I do about it?
Remember if you are aware of abusive behavior and do not speak out against it, your silence communicates implicitly that you see nothing unacceptable taking place.\)
Additional resources for those experiencing abuse in relationships:
https://www.loveisrespect.org/ / Call 1-866-331-9474 / Text LOVEIS to 22522
https://www.thehotline.org/ / Call 1.800.799.SAFE (7233) / Text START to 88788
submitted by Asleepfarm420 to apollostonesnark [link] [comments]

2023.06.04 19:11 ATeffect [WTS/WTT] Axil GS Extreme 2.0 In-Ear Protection $85

Timestamp: https://imgur.com/a/UbfdiUw
Brand new set of Axil GS Extreme 2.0 Ear Pros
SV/TV: $85 Shipped
Looking for: Ranger Green D3CRM, K19 Gen 3 RG, Holosun EPS Carry Green 2moa, Unity Hot Button Surefire 1913 and will add cash on my end if necessary
Payment, Shipping, & Transaction Info: NO G&S due to tax changes with paypal.
1 - Payment Methods: Paypal F&F, Venmo F&F, and Cashapp with NO NOTES IN DESCRIPTIONS. Use an emoji for Venmo.
2 - I use Pirate Ship to create labels and will provide tracking as soon as possible. Lower 48 only, no HI or AK.
4 - Call "dibs" to secure what you want. "Dibs" will have priority over "Interested" or "PM sent".
5 - Unless something is marked as SOLD, it is still available. Call 2nd Dibs, 3rd Dibs, etc. in a comment below.
6 - Buyer will have 1 hour to send funds. Item(s) will be passed to next in line if no funds are received within an hour. If you need more time just let me know.
submitted by ATeffect to GunAccessoriesForSale [link] [comments]


I’m not a native english speaker so sorry in advance if this post contains any grammatical errors. I’m neither a doctoresearcher or a science guy so I’ll try to alway provide some reference but be aware that the information that follows may be misinterpreted or simply not correct.
The aim of this post is to understand what is the consensus and the consolidated evidence on PE, and what information we should expect from a clinician/doctor (so you probably won’t find any new therapy you have never heard of). I’m curious and wanted to know a little bit more about this topic since I think there is a lot of misinformation and common beliefs that are rooted but are not backed up by any scientific evidence and even doctors/clinician sometimes are not educated enough on the topic to provide any actual help.Don’t expect anything super well summarised, this is going to be more of a copy and paste work.
Following the Hierarchy of Evidence in medical research meta-analysis, systematic reviews and practice guidelines provide the highest quality of evidence, I focused on the guidelines because I think that are more practical and have more reach to doctors/clinician that are not expert in the field. I found the ISSM’s (International Society of Sexual Medicine) guidelines to be the most complete guidelines on the topic. The International Society for Sexual Medicine (ISSM) is a medical society devoted to the study of the medicine of human sexuality. It publishes two journals, The Journal of Sexual Medicine (where the guidelines were published, IF for 2022-2023 is 3.9), and the open-access Sexual Medicine Reviews. The last update of the guidelines I found is from 2013/2014, American Urology Association has its own guidelines updated in 2020, they are not specifically focused on just PE but on Disorders of Ejaculation, mainly PE and DE (Delayed Ejaculation). The AUA’s guidelines focus mainly on the management of the patient and the pharmacotherapy and don’t give many indications about the main theories on PE’s causes.

Definition from ISSM

The panel proposed a unified definition of LPE (Long Term PE) and APE (Acquired PE):
It “is a male sexual dysfunction characterized by:
  • ejaculation that always or nearly always occurs prior to or within about 1 minute of vaginal penetration from the first sexual experience (LPE), OR a clinically significant reduction in latency time, often to about 3 minutes or less (acquired premature ejaculation);
  • the inability to delay ejaculation on all or nearly all vaginal penetrations; and
  • negative personal consequences, such as distress, bother, frustration, and/or the avoidance of sexual intimacy.”
It also identify additional subtypes: VPE (Variable PE) that occurs irregularly and inconsistently and SPE (Subjective PE) a subjective perception of PE but with the IELT in the “normal range” (so a IELT >= 3 mins, the median IELTs from 2 studies is 5.4 minutes and 6 minutes respectively).
The estimated prevalence of APE and LPE is around 5%, the prevalence of VPE and SPE is higher but these definitions are relatively new so there isn’t a lot of data.

Etiology (form ISSM’s guidelines)

I start by saying that of all the biological factors that have been proposed to explain PE, none has been confirmed in large scale studies, nonetheless some studies are really interesting.
Hypersensitivity of the Glans -> in a small study was found that patient with PE have hypersensitivity and hyperexcitability of the glans via performing somatosensory evoked potentials (brain responses to sensory stimuli). A similar study not cited in ISSM’s Guidelines is Zhang 2009 that found in a small cohort that patients with PE have on average a higher number of dorsal penile nerve branches. Disturbances in central serotonergic neurotransmission -> We know that Serotonin is the main neurotransmitter involved in the control of ejaculation, but in humans specific subtypes of 5-HT (serotonin) receptors involved in PE have not yet been identified. SSRIs work but SSRIs treatment activates many different postsynaptic subtype receptors so we don’t know specifically how it works. In the spinal cord, specific neurons have been found to be essential to ejaculatory reflex in rats and there is also preliminary evidence that such a neural organisation also exists in humans. Genetics of PE -> Some studies have investigated gene polymorphism of receptors of serotonin and oxytocin. Results of the studies are mixed, men with some genetic variants may be predisposed to develop PE but more studies are needed. Hormones imbalances -> Hyperthyroidism has no role in LPE and has been found to be associated with APW in extremely few patients. Recent studies on large population indicate that the endocrine system is involved in the control of ejaculatory function: prolactin in the lowest quartile levels is associated with APE and anxiety symptoms and higher testosterone levels aìcorrelate with PE, while lower androgenization is related to delayed ejaculation. Anyway the guidelines state that both low PRL and relatively high testosterone levels cannot be considered etiologies of PE. Prostatitis -> Prostatic inflammation and chronic bacterial prostatitis have been reported as common findings in men with APE. For the guidelines though there is insufficient evidence to support routine screening of men with PE for this condition. Erectile dysfunction -> For the guidelines ED is unlikely as a comorbidity or etiological factor for LPE, there is data to support that APE is associated with PE. Psychological factors -> there has been limited research on causality; most studies can only report association. It is plausible that psychological factors may lead to PE or vice versa, it is likely that for many men the relationship is reciprocal with either PE or the other factor causing exacerbation of the other.

Psychological/Behavioral interventions

There is not much to say on this topic, well designed studies on behavioural interventions are scarce, apart from the squeeze/start-stop technique other interventions are correct breathing and relaxation of the muscles to control excitement (discussed a lot in this community).

Pharmacological Treatment (from ISSM guidelines)

Dapoxetine: it is a rapid acting and short half-life SSRI with a pharmacokinetic profile supporting a role as an on demand treatment for PE. In randomised controlled trials, dapoxetine 30mg or 60mg taken 1-2 hours before intercourse is more effective than placebo from the first dose resulting in a 2.5 and 3.0 fold increase in IELT. Treatment-related side effects were uncommon, dose dependent and included nausea, diarrhoea, headache and dizziness: they were responsible for study discontinuation in 4% (30mg) and 10% (60mg) of subjects.
Off-Label SSRIs and TCAs: Daily treatment with off-label paroxetine 10-40 mg, clomipramine 12.5-50 mg, sertraline 50-200 mg, fluoxetine 20.40 mg and citalopram 20.40 mg is usually effective in delaying ejaculation. A meta-analysis of published data suggests that paroxetine exerts the strongest ejaculation delay, increasing IELT approximately 8.8-fold over baseline. SSRIs should be avoided in men with a history of bipolar depression.
Topical Local Anesthetics: lidocaine and/or prilocaine as a cream, gel, or spray is well established and is moderately effective in delaying ejaculation, data suggest that diminishing the glans sensitivity may inhibit the spinal reflex that are responsible for ejaculation. PSD502 (Fortacin in Europe) , a lidocaine-prilocaine spray applied 5 minutes before intercourse is associated with a 6.3-fold increase in IELT. There were minimal reports of penile hypoanesthesia and transfer to the partner due to the unique formulation of the compound.
PDE5i: SIldenafil, Tadalafil, Vardenafil, are effective treatments for ED, there is some evidence to support the efficacy and safety of off-label on demand or daily dosing of PDE5i in the treatment of LPE in men with normal erectile function but further evidence based research is encouraged to understand conflicting data.

Other pharmacological treatments

Tramadol: Tramadol has been investigated as a potential off.label therapy for PE, with several studies demonstrating efficacy, the mechanism of action is not completely understood. It may be considered when other therapies have failed because of the risk of addiction and side effects.
Oxytocin: Intraventricular administration of oxytocin antagonist inhibits sexual behaviour in animal studies, however in one human study, an oxytocin antagonist failed to clinically or statistically improve IELT, further human studies are necessary.
Alpha1-adrenoceptor antagonists: not mentioned in ISSM’s guidelines but in the AUA’s. There are not good quality studies on these drugs, Silodosin seems the most effective one. From AUA

Other treatments

Cryoablation and Neuromodulation of the Dorsal Penile Nerve: invasive and irreversible procedure, which is associated with an increase in the IELT. However, safety of this treatment modality needs to be determined before this procedure can be recommended for treating patients.
Intracavernosal Injection for PE: There is limited evidence regarding the efficacy of intracavernosal vasoactive drug injection for the treatment of PE.
Injections with hyaluronic acid in the glans: a study cited by AUA found a 2.6 fold increase vs 1.1 placebo in ELT, AUA recommends that surgical intervention for PE only to be considered in the context of ethical board approved trial for patients who have failed or cannot tolerate alternative management strategies for PE.

Preclinical studies for PE

Several agents have been studied in animal models for treating PE: a potent SSRI (DA-8031) significantly inhibited ejaculation in rat models. There are some human studies after 2013 (so after the publication of the guidelines) but I can’t understand in which phase the drug is and if the possible therapy with this SSRI is on-demand or not and the drug is not mentioned in AUA’s guidelines and I don’t understand why.
Modafinil, used in the treatment of narcolepsy, produced significant delay in ejaculation in rat models. Can’t find a lot of studies after 2013, in the AUA’s guidelines form 2020 it’s reported that in an uncontrolled pilot study of on-demand modafinil it’s reported a modest but significant two-fold increase in IELT.
Injection of botulinum toxin in the bulbospongiosus muscle, from AUA’s guidelines: the toxin that blocks neural transmission when injected into the muscle. But studies for PE were discontinued due to lack of efficacy in interim analysis.
Oxytocin antagonists (from AUA’s guidelines): Cligosoban is a oxytocin receptor antagonist that in a RCT double blind trial showed statistically significant effect of LPE men (3.6 fold increase in ELT vs 1.8 for placebo).
Further study and potentially development of agents with different distribution is required to determine if these therapies will have a role in PE management in the future.
submitted by roses4you to PrematureEjaculation [link] [comments]

2023.06.04 19:03 ForceBru Who came up with the moving variance estimator?

Apart from the usual (G)ARCH volatility models, there's this very basic method of estimating dynamic volatility called "rolling/moving variance" or "rolling window model of the conditional variance" [Guidolin & Pedio, 2018, sec. 5.2.1]. It's completely analogous to the rolling average and is defined as:
var[t] = avg{r[t]^2, r[t-1]^2, ..., r[t-W+1]^2} 
Here, {r[t]} are stock returns. Essentially, variances are computed for overlapping windows {r[t-W+1], ..., r[t-1], r[t]} assuming zero mean.
This seems simple enough, but I'm unable to find who invented this method. Or who first used it? Who explained why it can be used as a variance estimator?
Sure, it's a special case of ARCH with no additive constant and equal weights. However, it was known before ARCH (which appeared in 1982):
Does anyone know who introduced this way of estimating time-varying volatility?


  1. Guidolin & Pedio, "Time series for financial applications", 2018.
  2. Officer, R.R., "The variability of the market factor of the New York Stock Exchange", 1973.
  3. Merton, R.C., "On estimating the expected return on the market", 1980.
submitted by ForceBru to quant [link] [comments]

2023.06.04 18:55 SgathTriallair Why we need AI to fix our broken world

Based on Dave's new video (https://youtu.be/7WwqV0cBoGA).
There is a major problem here and that is the idea that we need to achieve energy abundance and international cooperation before we get ASI. Essentially, you are saying that if we don't achieve utopia before we get ASI then we are almost certain to get dystopia and extinction. Given that there is an absolutely zero percent chance we get there in the next 20 years and a practically zero chance we get there in the next 100 years, does this mean that the only solution is to completely stop all progress on AI immediately before we reach the typing point where the AI can improve itself?
We are already very close to, and have perhaps already passed, the point at which an AI is capable of being given agency and doing its own AI research. Granted, the most powerful and capable models are affiliated with large companies as they cost a lot to run but both anthropic and OpenAI were small shops before they produced their big model and Google and Microsoft invested in them rather than built them. So it is clear that a small shop can build a powerful AI and we are shrinking these models everyday through better chips and better algorithms. At some point in the very near future you will be able to build an AGI on a system that is affordable for a single household (i.e. costs as much as a house).
If you combine these two ideas, that we need to achieve utopia before we get ASI and that we'll be capable of building ASI (or at least starting it) within the next decade, the only possible solution is to institute a complete ban on computer progress. This would likely also need to be a ban on physics and other science as those can lead to breakthroughs that make computing cheaper and they will need more compute power to continue advancing. A ban this powerful, and world wide, will of necessity be one of the most ubiquitous police states in the world and will rival North Korea. The additional problem is that once you give the government the power to regulate any science or research, including hobbyists, then you have given so much power to the state that corruption is inevitable.
This world, where we stop AI now, is the dystopia we fear. We are proposing to build the very monster we fear in order to save us from itself.
I don't think it is possible to build the utopia until we have the AGI (or something close to it). I look at Marx for this. The economics of a society shape its power system. In a capitalist economy you have a few factors which shape or economy. The first is the division between labor and capital. The tools to produce value are expensive and difficult to obtain. Initially you needed massive factories and tracts of land. This limited ownership to all but the very few. For everyone else to survive, they needed to hitch themselves as laborers to one of these owners.
As time has increased technology has grown to reduce the amount of capital you need to create wealth. The FANG companies were funded by small entrepreneurs with home equipment. They did, however, have to attract large investments to grow. Silicon valley maintains this trend where amazing new tools (and really shitty ones) are created by individuals but that big capital is needed to rev them up. This is why the capitalist system maintains itself.
AGI is extra powerful because it allows a single person to do so much. (This is assuming AGI that is capable of replacing human labor but still needs human initiative.) This becomes more true as we move AI from million dollar super computers into people's homes. The individual will be able to compete on an unheard of level. The Internet tools that we all use will be replicable by any individual. Big investors won't be able to keep up as by the time they finish the paperwork to invest a new competitor has already shot up. Additional advances, like ubiquitous 3D printing, configurable factories, and eventually nano-replicators, will help eliminate the grip of physical manufactures.
As the capability gap between the investor class and the working class shrinks, the investor class will lose their power. A post-scarcity world will emerge, though it will likely involve many bloody conflicts. AGI is a primary tool we need to make this happen and so it, necessarily, must come before the utopia but after it. A hyper intelligent AI will be able to assess the situation and help us navigate towards the better society.
This is why, my theory is that the best method to build a utopian society is to get powerful AI into the hands of as many people as possible.
submitted by SgathTriallair to HeuristicImperatives [link] [comments]

2023.06.04 18:51 DeltaBot Deltas awarded in "Cmv: McDonald’s should have won the case where the lady spilled hot coffee on her...

Below is a list of the deltas awarded in this post.
Please note that a change of view is not necessarily a reversal, and that OP awarding a delta doesn't mean the conversation has ended.
For a full explanation of the delta system, see here.

Deltas from OP SignificantAd2222

Deltas from Other Users

None yet.
submitted by DeltaBot to DeltaLog [link] [comments]

2023.06.04 18:50 emposoeremg [GET] Kevin King – Billion Dollar Seller Summit 2023 (13.81 GB) Download

[GET] Kevin King – Billion Dollar Seller Summit 2023 (13.81 GB) Download

Kevin King – Billion Dollar Seller Summit 2023
Download Here: Kevin King – Billion Dollar Seller Summit 2023 (13.81 GB) Download
The Billion Dollar Seller Summit, hosted by Kevin King, is a game-changing online course that offers invaluable insights and strategies for individuals looking to establish and grow successful e-commerce businesses. With his extensive experience as a seasoned entrepreneur and Amazon expert, Kevin King provides a wealth of knowledge and practical advice to help participants navigate the complexities of the e-commerce landscape.
The Billion Dollar Seller Summit is designed to empower entrepreneurs at all levels, from beginners looking to launch their first product to experienced sellers aiming to scale their businesses to new heights. Kevin King's expertise and proven track record as a "billion-dollar seller" make him an authoritative and reliable guide throughout the course.
One of the standout features of the Billion Dollar Seller Summit is the comprehensive curriculum. The course covers a wide range of essential topics, including product research and selection, sourcing strategies, branding, marketing, inventory management, and optimization techniques. By exploring these key areas, participants gain a holistic understanding of the e-commerce ecosystem and the crucial factors that contribute to success.
Kevin King's teaching approach is highly practical and results-oriented. Rather than focusing solely on theory, he provides actionable strategies and tactics that participants can immediately implement in their own businesses. Through real-life case studies and examples, King demonstrates the effectiveness of his methods, enabling participants to apply them with confidence.
The Billion Dollar Seller Summit also places a strong emphasis on staying ahead of the curve in the ever-evolving e-commerce industry. Kevin King keeps the course content regularly updated to reflect the latest trends, changes in algorithms, and emerging opportunities. This commitment to delivering current and relevant information ensures that participants are equipped with the most up-to-date strategies and tactics to maximize their success.
In addition to the core course materials, participants of the Billion Dollar Seller Summit gain access to a vibrant and supportive community. The course provides a dedicated platform where entrepreneurs can connect, engage in discussions, and share experiences. This network of like-minded individuals offers invaluable support, collaboration opportunities, and ongoing learning resources.
Another standout feature of the Billion Dollar Seller Summit is the inclusion of expert guest speakers. Kevin King brings in industry leaders and subject matter experts who share their insights and expertise in specialized areas such as product photography, PPC advertising, listing optimization, and inventory management. These guest speakers enhance the course by providing additional perspectives and deepening participants' understanding of critical topics.
Upon completion of the Billion Dollar Seller Summit, participants will have gained a comprehensive understanding of the e-commerce landscape and the strategies required to build a successful online business. They will have the knowledge and tools to identify profitable product opportunities, source products effectively, optimize listings for maximum visibility, and navigate the complexities of marketing and advertising in the e-commerce space.
In conclusion, the Billion Dollar Seller Summit by Kevin King is a transformative online course that equips entrepreneurs with the knowledge, strategies, and resources needed to thrive in the world of e-commerce. With its comprehensive curriculum, practical approach, and commitment to staying current, this course empowers participants to build and scale successful businesses. By enrolling in the Billion Dollar Seller Summit, aspiring and established e-commerce entrepreneurs gain a competitive edge in their journey towards financial freedom and business success.
submitted by emposoeremg to learninghubgc [link] [comments]

2023.06.04 18:49 LeatherRoyal5149 Medical Use of Marijuana's For Dummies

Medical Use of Marijuana's For Dummies

Medical Use of Marijuana's
I hope I could retune to my early days in collage where I had access to crude marijuana for learning purposes, we had learned that these kind of crude plants are for extraction of active ingredients and can't be use as it's for medical purposes, I wish my teaches are here today witnessing smoking marijuana in the same way of getting high is used for medical purposes and has be legalized in many states to be dispensed in public pharmacies by official medical prescription


Marijuana, also known as cannabis, is a plant that has been used for both medicinal and recreational purposes for thousands of years. The plant is native to Central Asia and the Indian subcontinent, and it belongs to the family Cannabaceae. The use of marijuana can be traced back to ancient civilizations, including China, India, and Egypt. In modern times, marijuana has been a controversial topic due to its potential medical benefits and risks. This article will explore the history, botanical specifications, chemistry, active ingredients, mechanism of action, medical uses, and legislations related to marijuana.

Origin and History of Marijuana:

Marijuana has been used for thousands of years for medicinal and recreational purposes. The first recorded use of marijuana was in China around 2737 BC, where it was used to treat various ailments such as rheumatism, malaria, and constipation. In India, marijuana was used in religious ceremonies and for medicinal purposes. The ancient Egyptians also used marijuana for medicinal purposes, including treating glaucoma and inflammation. Marijuana was introduced to the Western world by Napoleon's soldiers, who brought it back to France from Egypt in the early 19th century.

Botanical Specifications of Marijuana:

Marijuana is an annual plant that can grow up to 18 feet tall. The plant has a distinctive appearance with serrated leaves that are arranged in a spiral pattern around the stem. The male and female flowers of the plant are located on separate plants. The female flowers are more potent and contain higher levels of THC (tetrahydrocannabinol), the primary psychoactive ingredient in marijuana.

Marijuana's Active Parts and Extracted Active Ingredients:

Marijuana contains over 100 different compounds, including cannabinoids, terpenes, and flavonoids. The primary active ingredients in marijuana are THC and CBD%20and%20THC%20(,has%20a%20lot%20of%20CBD.) (cannabidiol). THC is the primary psychoactive compound in marijuana, which gives users the feeling of being "high." CBD, on the other hand, does not have psychoactive properties and has been shown to have potential therapeutic benefits.

Chemistry of Marijuana:

Marijuana contains cannabinoids, which are a group of compounds that interact with the body's endocannabinoid system. The endocannabinoid system is a complex cell-signaling system that plays a role in regulating various physiological processes, including pain, mood, appetite, and sleep. THC and CBD bind to specific receptors in the endocannabinoid system, which can result in various physiological effects.

Active Ingredients Mechanism of Action:

THC and CBD have different mechanisms of action. THC binds to CB1 receptors in the brain, which can result in the feeling of being "high." THC also has analgesic, anti-inflammatory, and antiemetic properties. CBD, on the other hand, does not bind to CB1 receptors and has a more complex mechanism of action. CBD has been shown to have potential therapeutic benefits for various conditions, including epilepsy, anxiety, and inflammation.

First Call of Medical Use:

The first call for the medical use of marijuana in modern times was in 1839 by William O'Shaughnessy, an Irish physician who worked in India. O'Shaughnessy conducted a study on the use of marijuana as a treatment for various conditions, including cholera, tetanus, and rabies. He found that marijuana had potential therapeutic benefits and could alleviate symptoms associated with these conditions.

Legislations, Allowed States, and Countries:

Marijuana is illegal under federal law in the United States, but many states have legalized it for medicinal and/or recreational use. As of 2021, 36 states and the District of Columbia have legalized marijuana for medicinal use, while 15 states and the District of Columbia have legalized it for recreational use. In Canada, marijuana was legalized for recreational use in 2018. Many other countries, including Germany, Israel, and Australia, have legalized marijuana for medicinal use.

Medical Uses:

Marijuana has been shown to have potential therapeutic benefits for various conditions, including chronic pain, nausea and vomiting associated with chemotherapy, spasticity associated with multiple sclerosis, and epilepsy. THC has been shown to be effective in reducing pain and inflammation, while CBD has been shown to have potential therapeutic benefits for anxiety, depression, and epilepsy.

Dosage Forms:

Marijuana can be consumed in various forms, including smoking, vaporizing, edibles, tinctures, and topicals. Smoking and vaporizing are the most common methods of administration, but edibles and tinctures are becoming increasingly popular due to their longer-lasting effects and ease of use.


Marijuana has been used for thousands of years for medicinal and recreational purposes. The plant contains various compounds, including cannabinoids, terpenes, and flavonoids, that interact with the body's endocannabinoid system. THC and CBD are the primary active ingredients in marijuana and have different mechanisms of action. Marijuana has been shown to have potential therapeutic benefits for various conditions, including chronic pain, nausea and vomiting associated with chemotherapy, spasticity associated with multiple sclerosis, and epilepsy. However, there are also potential risks associated with marijuana use, including addiction, impaired cognitive function, and respiratory problems. It is important to weigh the potential benefits and risks of marijuana use and to consult with a healthcare provider before using marijuana for medicinal purposes. Furthermore, it is important to note that the legal status of marijuana varies by state and country, and users should be aware of the laws and regulations in their area. Overall, the medical use of marijuana has potential benefits, but it is important to use it responsibly and in consultation with a healthcare provider.
submitted by LeatherRoyal5149 to medicinfordummies [link] [comments]

2023.06.04 18:47 BreakingTheIce73 Sugar Daddy for Sugar Baby in Louisiana (Open to Arkansas, Mississippi, or Texas)

Clarification Note

- This is a new post format I am trying out on different platforms.
- I am going to be more direct in this post, that said if you do not fit the criteria in my post please do not contact me unless you're seeking friendship.
- I am interested in a sugaring dynamic added to BDSM, this takes time. If you want a buyer or a John please avoid me.
- If you're out of country, refer to the first note.

Special NoteIt's Sunday. If you're still hung over, and or still going to have your fun take care of yourself - eat some protein and drink plenty of water. If you have an extreme headache and over the counter meds aren't helping and you're still wanting to be a masochist cayenne pepper mixed with warm water will do the trick. Aside from that, if you do not read this entire post I'll know.

Side Note
If you're curious to get to know me, just ask.

All about what I am looking for and offer

- Age range 18 - 28.
- Good Hygiene, you can take care of yourself mentally and physically.
- CIS Female
- Body Type Preference: Slim/Petite to average and or curvy.
- Switches, Switchtastic times are the best times. Slaves, littles, and subs are nice as well though.
- Positive influence, that goes both ways in expectancy.
- Conversation, if you hit me with the ole buy meh nudes I will meme you. If you hit me with with the ole Daddy comment imma hit you with the worst site I can think of which is currently omegle.
- Gamers - preferably a female but if you're a guy and do competitive gaming I am open to a mutually beneficial arrangement in the realm of gaming.
- You're in Louisiana, yes this unfortunately dead state it seems. But if you're in the surrounding states I am open to it.
- Adrenaline junkie - We only have one life, might as well test it a little by zip lining or jumping out of a plane together.
- An Adult, if you've attempted to meet and or have met someone from here or other platforms you know what I am speaking of.
- BDSM, be into it and or open to being guided in it.
- Kinky Oranges, this better be in your first message to me.

Dynamics I align with best
Equal Ownership
Master to slave
Daddy to little
Owner to pet
Care Giver to little

Payment Methods I work with
- Google pay (primary option)
- Amazon Wish List (secondary only, meant for gifts)
- Gift Cards (secondary only, meant for gifts)
- The Dollar (because reddit doesn't like the C word for some reason) (primary option)
- Ko-fi's site (primary option)
- CA (primary option)
- Open to other alternatives if asked.

How my arrangement works
This is meant to be long term, it's going to take time to establish a connection and trust. If you're expecting to talk to me for 2 hours and get 400$ it's not going to happen. Ironically, I was scammed last month out of a starting trial period with a real person for 400$ after speaking to that person for two weeks. I don't always take two weeks to get to know someone but it depends on the vibes. For additional context, I believe this platform does not like the discussion of allowances in post so I will be omitting the allowance amounts from all stages.

Where you and I will be when you decide to reach out to me. We'll get to know the other from our vanilla life to our experience in the kink life, learning of the others limitations and interest. At some point I am going to prompt us both to do a SFW verification via call and or picture exchange. Silverware is a thing so don't be surprised if I prompt for something random. I will likely prompt for at least 1 - 2 calls, if we mesh then we mesh. If we don't then we can agree for friendship or parting ways.

If in Louisiana - The above will take place first, then an initial meet to a restaurant will be prompted. I will cover all expenses, and if needed support travel. If we mesh we mesh, if we do not mesh we can part ways and or maintain a friendship.
In this stage, we've agreed we mesh in chemistry and wish to push forward.
This is a two week trial. In this trial a light core dynamic will begin, I will take on the Dominant role regardless if you're a switch or not. I expect moderate time to be given while we continue to engage with the other. This will include a bare basic rule system to give a glimpse of interest in real time, light NSFW play, and establishing further trust in the other.

If in Louisiana - The above will likely be online. Meets to restaurants and or events will be expected. This is SFW.

In this stage, we've agreed we still mesh in kink and chemistry and wish to push forward.
This will continue into a two week allowance arrangement with occasional gifts. The allowance will be raised from the trial period. This stage will consist through a time span of 2 - 6 months. I will maintain the Dominant role at least for the start dependent on our interest for dynamics. This will be a true start to a generic Dom / sub dynamic that will merge into others as time passes with moderate rules and guidance both in kink and your life as I wish to push you toward your goals. NFSW and SFW.

If in Louisiana - I do expect regular meets which will be determined together, it will be SFW and NSFW for scene play and or sessions along with outtings. Sadistic Pineapples better be in your first message.

If out of state - Semi regular to regular meets are expected. Travel will be covered. First meet will be SFW if you are uncomfortable for anything beyond.

We've established that we're both in it for the long run. We will either maintain two week allowance periods or weekly allowance periods dependent on what we're looking for. Gifts are regular. A true formality collar is introduced, if you're interested I also have a role play based BDSM contract. A true dynamic will be established between us with my full list of rules, guidance and scene play.
submitted by BreakingTheIce73 to SugarBabyGroups [link] [comments]

2023.06.04 18:35 KyoumaGames I believe I have found a fix for the "Updated" date not updating bug whenever someone uploads an update to their world

Tl;Dr: while Unity is sending the update of your world to vrchat's servers, spam updates to your world's description on vrchat's site the entire time. I'd do this by adding a period to my description and then saving changes, rinse and repeating until Unity was done. There's a window of time while Unity updates your world that you have to catch with a website update at the same time, so the faster you save changes on the site, the better chance you have at hitting that window.
That title is confusing. Anyways, I have been testing non stop how to fix this bug. It's the one where if you upload a change to your world, the Updated date for your world's info doesn't change to Today's date, resulting in you not getting the "Updated Recently" tag or showing up in the Updated Recently category. And I think I have finally found a solution.
I have tested this four different times and it has worked all four times so it's hard for me to label it as coincidence. Especially since I can upload my world 20 times in a row without doing this thing and it never change the Updated date but it'll change it on my first or second upload whenever doing this method (it not working on my first attempt has an explanation further below).
Here's the possible fix: I would see commonly that people used to mention how just putting a period in your world's description and saving it on the site would change the Updated date but that didn't really seem to work anymore. So I did a thing. I spammed period updates in my description on the site WHILE my world was in its final leg of uploading. At some point, during the upload process, there is a small window where if you update your world's description on the site at the same time, it'll change your Updated date. I don't know where that window is and I have missed it a couple of times but it always works on my second attempt, so you have to be fast. The slower you are, the more times it might take you because you miss that window.
Basically, what I would do is I'd let Unity compile the upload and then when I got to the upload screen (where I can name my world and give it a description, etc), I'd put unity on one half of my screen and the vrchat site on the other half of my screen, ready to edit my world's description. I'd then click Update on my world (or upload, whatever it says, I forget) in Unity, and then immediately go over to the website and start spamming period updates. I'd add a period to the description, quickly click Save Changes, then add another period to the description, quickly click Save Changes, repeat repeat repeat, I'd do this as fast as I could until Unity was finished with it's upload (about 30-60 seconds). I'd then delete all of the periods, save changes, and hopefully the date had changed. Twice it changed on the first attempt. Two other times it didn't because I must've not saved changes during the window of time I needed to, but then I'd catch that window on my second attempt. It might take you three or four tries, but the faster you go, the more chances you have of hitting that window.
Please let me know if this works for you or if not and how many times you tried in a row
submitted by KyoumaGames to VRchat [link] [comments]

2023.06.04 18:28 Loose-Patient-5370 How To Change Your Grade On PowerSchool//How do I change my students grade on PowerSchool? How do I change my grade on PowerSchool app? How do I fix my grade level on PowerSchool? How do you change a grade? 📷

[[email protected]](mailto:[email protected]) ---------------------------- Sometimes, people get lucky. You might only need to hack your teacher’s, lecturer’s or professor’s email to change the grade. It all depends on how thorough you are with making research on the job. That is why we advise that you HIRE [J](mailto:[email protected])essica the proper professional hacking tools and expertise to get the job done for you.
What is PowerSchool?
PowerSchool SIS is a Student Information System in form of web-based application designed for schools. It makes it easy for parents and students to log into a secure account from home, school or work; access real-time assignments, grades and attendance; request reports, email teachers and do more.
PowerSchool tracks student records and progress. School administrators and teachers enter data into the system, where it is stored. When you need to access the information, you can perform searches and run reports. Parents can monitor their children’s progress and learn about school activities.
How Secure is PowerSchool?
PowerSchool hosting is delivered through Microsoft Azure cloud-based technology. All cloud models are susceptible to threats. However, Cloud Computing centralizes applications and data making it very easy to detect hacking if any of the data is tampered with. Though it is secured to some extent it can still be hacked by a very good hacker.
How to Hack PowerSchool Without Being Noticed
Trying to gain unauthorized access to PowerSchool SIS could be very stressful and dangerous (if caught). It is always important to know the status of the college or University’s cyber-security, database protocol and security review periods when trying to change grades or collect data from the school’s database when the grades are uploaded otherwise change of grades might not need hacking the whole school’s system.
Sometimes, people get lucky. You might only need to hack your teacher’s, lecturer’s or professor’s email to change the grade. It all depends on how thorough you are with making research on the job.
Contact us at [[email protected]](mailto:[email protected]) for technical problems about your task or issue regarding hacking services.Change Your Grade Without Hacking the Whole School System
There will be no need to hack the whole database of the school if you can find a way to get into the mail of your professor or teacher (as the case maybe) especially if the grade has not been uploaded or updated on the central Database. This is less risky but still requires expertise. Know that these acts are also illegal.
Factors To Consider in Hacking Central Database
To wrap it up, schools are using PowerSchool because it is more secured but it does not mean it cannot be hacked. Hacking platforms like PowerSchool requires great expertise, professional hacking tools and experience. It is usually advisable to employ the service of Jessica via email at [[email protected]](mailto:[email protected])
submitted by Loose-Patient-5370 to u/Loose-Patient-5370 [link] [comments]


Back in style are fiberglass nails. It makes sense because they provide nails a manicure that looks natural and causes less damage to them. Even if pretty nail art there aren't many salons that provide this service, you can still do them at home. Everything you need to know about fiberglass nails will be covered in this post.


The fact that fiberglass nails are less harmful to natural nails than acrylics and don't require as much skill to apply is one of the factors contributing to their rising popularity. They are also a lot simpler to get rid of.
However, acrylic nails will endure longer than fiberglass nails. They cannot be used to construct an arch on flat nails, which is another downside. However, you can simple nails art form the points into a curved shape using clamps.


The strength and longevity of fiberglass nails are superior to those of silk nails. They are therefore perfect for people seeking a compromise between lightweight extensions and long-lasting wear.


These nail extensions have a two-week lifespan after application. Additionally, if fiberglass nails are exposed to water often, they may chip, lift, or even develop mold. If you're going to be doing the dishes or other comparable tasks, it's a good idea to wear rubber gloves.


The resin in fiberglass nails dries by air, thus they don't need a nail lamp to cure. The adhesive also has a milder scent than acrylics, making it more enjoyable to work with.
There is no need for a drill when shaping fiberglass nails once they have dried; just use a nail file. Then, they can be painted in an infinite number of different styles and designs using acrylic or gel polish. On the other hand, they can resemble a natural nail if they are simply finished with a top coat.
A short dip in acetone will remove fiberglass nails when the time comes. No need to spend a lot of time grinding.


Applying fiberglass nails properly involves the following steps:
To guarantee a suitable fit, it is essential to first compare the sizes of the fiberglass wrap to those of your natural nails. Before anything else, complete this.
The following step is to get ready by cutting, shaping, and lightly buffing your nails to take off the sheen. Eliminate any oil, polish, or dirt that is already present. After that, use a nail wipe or rubbing alcohol to remove any leftover residue from the nail surface.
It's time to apply the resin simple nail ideas after your nails are ready. In order to ensure consistent covering, apply a thin coating of resin to the nail surface. Before the adhesive base dries, press the fiberglass wrap into position while making sure there are no air bubbles or wrinkles in the wrap.
Trim the fiberglass to the required length once the wrap is in place. Use a good pair of scissors.
Apply more resin next to ensure a smooth finish and to shield the fiberglass from harm. While the resin dries, gently curl the nail with nail-shaping tweezers or clips. This method gives your nails a natural-looking form and increases their structural durability.
File the nail augmentation to perfect its shape and smooth any rough edges after the resin or gel has completely dried.



Any nail augmentation, if not done and removed properly, could weaken the natural nails. The good news is that fiberglass nails only need a minimal amount of preparation before use. Acidic primers and extensive filing are not necessary. Additionally, they can be quickly removed with an acetone-based polish remover. The greatest risk is being exposed to water. Fungus may grow there if moisture becomes trapped between the fiberglass and the nail.


Press-on nails are without a doubt the simplest, quickest replacement for fiberglass wraps. The majority of brands include adhesive in the package, giving you the option to select between nail glue or double-sided sticky tape depending on how durable you want your manicure to be.
Additionally, press-on nails can be painted to beautiful nail designs 2022 seem like fiberglass nails. The only drawback is that, unlike fiberglass wraps, standard press-ons are opaque and do not resemble genuine nails.
Soft gels are the next most straightforward solution. They come in clear covers or transparent nail extensions.
submitted by SavingsSpare8104 to u/SavingsSpare8104 [link] [comments]

2023.06.04 18:12 Chemical-Carry-5228 4P Model instead of diagnosis

Okay, my last therapist shared a different way to describe a patient's situation rather than a diagnostic label. I've read the article above and find this method dehumanizing and infuriating. Squeezing someone into 12 boxes, most of which are pathologized states. Like how the hell being poor is a pathology.
I insisted on no diagnosis, and that did not work. I don't want to be described in 12 boxes, this feels very insulting to me. Or perhaps if I ever go see that therapist again, I might suggest we first describe him by this table, than me, so that I don't feel abused.
submitted by Chemical-Carry-5228 to therapyabuse [link] [comments]

2023.06.04 18:01 Big-Research-2875 Activation of Egg Metabolism

Activation of Egg

Although fertilization is commonly considered solely the suggests that to mix 2 haploid nuclei, however it's AN equally necessary role in initiating the processes that begin development.


A series of morphological, physiological, and molecular changes that occur within the egg in response to fusion of the spermatozoon with the egg is named is named Activation.
Activation of Egg Metabolism

Mechanism of Egg Activation:

All the activation events happen within the protoplasm and occur while not the involvement of the nuclei. The mature egg may be a metabolically inactive cell that's activated by the spermatozoon.The spermatozoon act sort of a massive secretion, binding to receptors on the egg membrane in all probability via G macromolecule that activate Srckinas, that activate PLC, that via IP3 and DAG increase animate thing factor IV add increase hydrogen ion concentration (alkaline) severally that activate egg.This flux of Ca across the eggs starts a programmed set of metabolic events.

G Protein:

G macromolecule conjointly called G ester binding macromolecule, ar a family of macromolecule that acts as a molecular switches within cell and ar concerned in transmittal signal from a spread of stimuli outside the cell to its interior.

Srckinase Function;

It is non receptor macromolecule amino acid enzyme,that ar concerned within the management of a spread of cellular method like,Proliferation,Differentiation,Motility andAdhesion.

submitted by Big-Research-2875 to Thinkersofbiology [link] [comments]

2023.06.04 18:00 BadBacon177 Chance Me For Aerospace Engineering At GATech or UMich

Demographics: White, lived in New Jersey my whole life in a middle-upper-class family. I attend a very competitive high school: The average SAT is around 1450, and around 7/60 kids per grade get into Ivy League Schools
GPA: 3.87 UW/4.37 W
Class Rank: My school does not do class rank since it is a specialized high school for gifted teenagers.
Coursework: Every class I have taken at my high school is AP level, but it is not an AP class. In other words, it is not labeled as an AP class but I have taken three AP exams without studying for them and got 5's on all of them just by taking the class. I also have 12 college credits from taking certain classes throughout my high school career.
AP Tests: 5 on the AP chemistry test, 5 on the AP Environmental Science test, and 5 on the AP Human Geography test.
SAT and ACT: 1480 (780 Math/ 700 English), 32 ACT
Awards: Nothing notable, won a county science fair for an independent research project freshman year, and I have the biliteracy seal for Spanish.
LOR and Essays: Great LORs from my chemistry, Spanish, and physics teachers. I have two essays that I believe are good, and have been proofread by every person I could get them proofread by. Examples are my family, my friends that are good at writing, and my 3 English teachers.
Intended Major: I would like to go for Aerospace Engineering
Chance Me: Georgia Tech and the University of Michigan are my main two, but also any other great schools you can think of for aerospace engineering would be helpful.
submitted by BadBacon177 to chanceme [link] [comments]

2023.06.04 17:45 Fuck_Birches Simple zinc plating of steel that won't corrode aluminum?

I'm trying to zinc-plate a steel part, however that part has alluminum that has been pressed on and cannot be removed.
I've read that vinegar plating zinc is a poor method of zinc plating due to a nonuniform coating and that it'll corrode the aluminum. What is an easily accessible (either to buy or produce) electrolyte that I could use?
From my basic chemistry knowledge it seems like ZnCl and ZnPO4 are not simple to make nor acquire but maybe I'm wrong? ZnOH also seems like it'll eat the aluminum. Maybe if I make a eat solution of ZnOH it won't eat the aluminum but will still allow for plating?
submitted by Fuck_Birches to chemhelp [link] [comments]

2023.06.04 17:43 Impressive_Isopod_44 Probably one of the most stereotypical ExTJ I’ve seen.

Some compilation footage of Mick Coup, a self-defence instructor. (Main Video Link: https://youtu.be/1m_jPckeqrc)
I didn’t want to succumb to stereotype but I definitely placed the ENTJ label on him immediately. I could say I felt all of this pointed towards attitudes that were obviously something whatever, Te-Se that..
But honestly, I just thought clear-cut confrontational vibes (maybe its just the nature of his job), focus on efficiency with realistic objective standards in mind, the scientific method all that, I guess an intuitive explanation of why things are the way they are. Physically built and imposing, commanding presence, British. If I said I didn’t just think “Gordon Ramsay ass mf” I’d be lying. Anyone could give a more accurate typing?
submitted by Impressive_Isopod_44 to mbti [link] [comments]